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Chemical Structure : CTDP-32476
Catalog No.: PC-35476Not For Human Use, Lab Use Only.
CTDP-32476 is a potent and selective dopamine transporter (DAT) inhibitor and a competitive inhibitor of cocaine binding to the DAT with Ki of 12 nM.
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CTDP-32476 is a potent and selective dopamine transporter (DAT) inhibitor and a competitive inhibitor of cocaine binding to the DAT with Ki of 12 nM.
CTDP-32476 demonstrates 20-fold higher affinity for the DAT than cocaine.
CTDP-32476 is more potent than methylphenidate in blocking [3H]-cocaine binding.
Systemic administration of CTDP-32476 alone produced a slow-onset, long-lasting increase in extracellular nucleus accumbens DA, locomotion, and brain-stimulation reward, inhibited cocaine self-administration, cocaine-associated cue-induced relapse to drug seeking, and cocaine-enhanced extracellular DA in the nucleus accumbens.
| M.Wt | 302.283 | |
| Formula | C16H25Cl2N | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xi ZX, et al. Neuropsychopharmacology. 2017 Feb;42(3):682-694.
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