Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : CTN06
Catalog No.: PC-35180Not For Human Use, Lab Use Only.
CTN06 is a potent Etk (BMX) and Btk dual inhibitor with IC50 of 200 and 50 nM, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
CTN06 is a potent Etk (BMX) and Btk dual inhibitor with IC50 of 200 and 50 nM, respectively.
CTN06 weakly inhibits Itk (IC50=0.5 uM), and shows no inhibition on Src (IC50=5 uM) and Mer (IC50=10 uM).
CTN06 effectively kills PC3 and other prostate cancer cells, induces autophagy as well as apoptosis in prostate cancer cells.
CTN06 inhibits the phosphorylation of Btk, Etk and the downstream signal PLCγ2, Stat3, Akt in prostate cancer cells.
CTN06 inhibits PC3 xenograft tumor growth in vivo.
| M.Wt | 563.706 | |
| Formula | C33H37N7O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Guo W, et al. Cell Death Dis. 2014 Sep 4;5:e1409.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
