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CTN06

Chemical Structure : CTN06

CAS No.:

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CTN06 (BMX/BTK inhibitor CTN06)

Catalog No.: PC-35180Not For Human Use, Lab Use Only.

CTN06 is a potent Etk (BMX) and Btk dual inhibitor with IC50 of 200 and 50 nM, respectively.

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    Biological Activity

    CTN06 is a potent Etk (BMX) and Btk dual inhibitor with IC50 of 200 and 50 nM, respectively.
    CTN06 weakly inhibits Itk (IC50=0.5 uM), and shows no inhibition on Src (IC50=5 uM) and Mer (IC50=10 uM).
    CTN06 effectively kills PC3 and other prostate cancer cells, induces autophagy as well as apoptosis in prostate cancer cells.
    CTN06 inhibits the phosphorylation of Btk, Etk and the downstream signal PLCγ2, Stat3, Akt in prostate cancer cells.
    CTN06 inhibits PC3 xenograft tumor growth in vivo.

    Physicochemical Properties

    M.Wt 563.706
    Formula C33H37N7O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(7-isobutyl-6-oxo-1-(3-(piperidin-1-yl)propyl)-5,6-dihydro-1H-imidazo[4,5-g]quinoxalin-2-yl)-4-(pyridin-4-yl)benzamide

    References

    1. Guo W, et al. Cell Death Dis. 2014 Sep 4;5:e1409.

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