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Chemical Structure : CUDC-101
CAS No.: 1012054-59-9
Catalog No.: PC-42467Not For Human Use, Lab Use Only.
CUDC-101 is a potent, multi-targeted HDAC, EGFR and HER2 inhibitor with IC50 of 4.4, 2.4, and 15.7 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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CUDC-101 is a potent, multi-targeted HDAC, EGFR and HER2 inhibitor with IC50 of 4.4, 2.4, and 15.7 nM, respectively.
CUDC-101 exhibits efficient antiproliferative activity with greater potency (IC50<1 uM) than Vorinostat (SAHA), Erlotinib, Lapatinib。
CUDC-101 promotes tumor regression or inhibition in various cancer xenograft models including NSCLC, liver, breast, head and neck, colon, and pancreatic cancers.
| M.Wt | 434.4876 | |
| Formula | C24H26N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Heptanamide, 7-[[4-[(3-ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-N-hydroxy- |
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1. Cai X, et al. J Med Chem. 2010 Mar 11;53(5):2000-9.
2. Lai CJ, et al. Cancer Res. 2010 May 1;70(9):3647-56.
3. Wang J, et al. Mol Cancer Ther. 2013 Jun;12(6):925-36.
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