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Chemical Structure : CUO246
Catalog No.: PC-49550Not For Human Use, Lab Use Only.
CUO246 (CUO-246) is a potent, selective bacterial DNA gyrase/topoisomerase IV inhibitor, CUO246 is active in vitro against a broad range of Gram-positive, fastidious Gram-negative, and atypical bacterial pathogens.
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CUO246 (CUO-246) is a potent, selective bacterial DNA gyrase/topoisomerase IV inhibitor, CUO246 is active in vitro against a broad range of Gram-positive, fastidious Gram-negative, and atypical bacterial pathogens.
CUO246 retained activity against quinolone-resistant strains in circulation.
CUO246 showed rapid bactericidal activity in time-kill assays and potent in vivo efficacy against S. aureus in a neutropenic murine thigh infection model.
| M.Wt | 387.41 | |
| Formula | C20H22FN3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Johanne Blais, et al. Antimicrob Agents Chemother. 2022 Dec 20;66(12):e0092122.
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