CVB4-57

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Chemical Structure : CVB4-57

Catalog No.: PC-24611Not For Human Use, Lab Use Only.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CVB4-57 is a specific, reversible small molecule Connexin26 hemichannel (Cx26 hemichannel), reversibly inhibited the dye uptake at 5 uM without affecting the gap junction communication and barrier function.
CVB4-57 (1 uM) decreases the dye uptake in cells expressing hCx26 to 79 ± 17%.
CVB4-57 (20 uM) decreases the dye uptake in N2A cells expressing Cx46 to 72 ± 3%.
CVB4-57 could block Cx hemichannels with minimal impact on the epithelial physiology.
Cx26 hemichannels are more sensitive to both agents compared to Cx46.

Physicochemical Properties

M.Wt	405.34
Formula	C20H25BrN2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-(4-(3-bromo-4-methoxybenzyl)piperazin-1-yl)ethyl)phenol

References

1. Dierks A, et al. Pharmaceuticals (Basel). 2022 Sep 21;15(10):1173.

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CVB4-57

Biological Activity

Physicochemical Properties

References

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