Chemical Structure : CVM-6-139-1
CAS No.:
1365986-44-2
CVM-6-139-1
(HIPK2 inhibitor A64)
Catalog No.: PC-73291Not For Human Use, Lab Use Only.
CVM-6-139-1 (HIPK2 inhibitor A64) is a potent small molecule HIPK2 kinase inhibitor, blocks HIPK2 phosphorylation on S359/T360 and JNK activation in HEK293 cells and attenuates ER stress-induced cell death with EC50 of 401 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CVM-6-139-1 (HIPK2 inhibitor A64) is a potent small molecule HIPK2 kinase inhibitor, blocks HIPK2 phosphorylation on S359/T360 and JNK activation in HEK293 cells and attenuates ER stress-induced cell death with EC50 of 401 nM.
CVM-6-139-1 blocks p-HIPK2 [S359/T360] in primary spinal motor neurons and protected >60% of these neurons from tunicamycin- and SOD1G93A-induced cell death.
CVM-6-139-1 attenuates TDP-43 proteinopathy-induced cell death in HEK293 cells and spinal motor neurons.
CVM-6-139-1 protects neurons from cell death induced by either wild type or mutant TDP-43.
Physicochemical Properties
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M.Wt
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383.426
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Formula
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C18H17N5O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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References
1. Sebum Lee, et al. Neuron. 2016, 91(1), 41-55.
2. Miduturu CV et al. Chem Biol. 2011;18:868–879.
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