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Chemical Structure : CVN293
Catalog No.: PC-22344Not For Human Use, Lab Use Only.
CVN293 (CVN-293) is a potent, selective and brain permeable potassium (K+) ion channel KCNK13 (THIK-1, K2P13.1) inhibitor with IC50 of 41 nM and 28 nM for human and mouse KCNK13, respectively.
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CVN293 (CVN-293) is a potent, selective and brain permeable potassium (K+) ion channel KCNK13 (THIK-1, K2P13.1) inhibitor with IC50 of 41 nM and 28 nM for human and mouse KCNK13, respectively.
CVN293 demonstrates minimal inhibition for most closely related channels KCNK2 and KCNK6 at 10 uM.
CVN293 blocked the release of IL-1β from microglia in a concentration-dependent manner, with a potency of 24 nM.
CVN293 (1 uM) attenuated the LPS/ATP-induced release of IL-1β in mouse cultured hippocampal slices.
CVN293 potently inhibits the NLRP3-inflammasome mediated production of the proinflammatory cytokine IL-1β in microglia.
| M.Wt | 311.28 | |
| Formula | C14H10FN7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bürli RW, et al. ACS Med Chem Lett. 2024 Apr 5;15(5):646-652.
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