Catalog No.: PC-38545Not For Human Use, Lab Use Only.
CVT-11127 (FMK13918, GS-456332) is a specfiic small molecule stearoyl-CoA desaturase (SCD) inhibitor with IC50 of 210 and 410 nM against rat microsomal SCD and HepG2 SCD, respectively.
CVT-11127 (FMK13918, GS-456332) is a specfiic small molecule stearoyl-CoA desaturase (SCD) inhibitor with IC50 of 210 and 410 nM against rat microsomal SCD and HepG2 SCD, respectively.
CVT-11127 is selective for Δ9 desaturases, does not inhibit the activity of rat microsomal Δ5 and Δ6 desaturases at 30 uM.
CVT-11127 reduces cell proliferation in human lung and breast cancer cells, decreases de novo lipid synthesis from glucose.
CVT-11127 impairs the ligand-induced phosphorylation of epidermal growth factor (EGF) receptor, causing the inactivation of its downstream targets Akt, ERK and mammalian target of rapamycin in H460 lung cancer cells.
