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Chemical Structure : CVT-11127
CAS No.: 1018674-83-3
Catalog No.: PC-38545Not For Human Use, Lab Use Only.
CVT-11127 (FMK13918, GS-456332) is a specfiic small molecule stearoyl-CoA desaturase (SCD) inhibitor with IC50 of 210 and 410 nM against rat microsomal SCD and HepG2 SCD, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $218 | In stock | |
| 10 mg | $348 | In stock | |
| 25 mg | $558 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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CVT-11127 (FMK13918, GS-456332) is a specfiic small molecule stearoyl-CoA desaturase (SCD) inhibitor with IC50 of 210 and 410 nM against rat microsomal SCD and HepG2 SCD, respectively.
CVT-11127 is selective for Δ9 desaturases, does not inhibit the activity of rat microsomal Δ5 and Δ6 desaturases at 30 uM.
CVT-11127 reduces cell proliferation in human lung and breast cancer cells, decreases de novo lipid synthesis from glucose.
CVT-11127 impairs the ligand-induced phosphorylation of epidermal growth factor (EGF) receptor, causing the inactivation of its downstream targets Akt, ERK and mammalian target of rapamycin in H460 lung cancer cells.
| M.Wt | 512.391 | |
| Formula | C25H23Cl2N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(2-(6-(3,4-dichlorobenzylamino)-2-(4-methoxyphenyl)-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl)ethyl) acetamide |
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1. Koltun DO, et al. Bioorg Med Chem Lett. 2009;19:2048–52.
2. Natalia Scaglia, et al. PLoS One. 2009 Aug 27;4(8):e6812.
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