Chemical Structure : CW-3308
CAS No.:
CW-3308
(CW3308)
Catalog No.: PC-22939Not For Human Use, Lab Use Only.
CW-3308 is a potent, selective, and orally bioavailable BRD9 PROTAC degrader, effectively reduces the BRD9 protein by 68% at 1 nM (DC50 < 1 nM) and 90% at 10 nM in the G401 rhabdoid tumor cell line.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CW-3308 is a potent, selective, and orally bioavailable BRD9 PROTAC degrader, effectively reduces the BRD9 protein by 68% at 1 nM (DC50 < 1 nM) and 90% at 10 nM in the G401 rhabdoid tumor cell line.
CW-3308 also effectively induced depletion of BRD9 protein in the HS-SY-II synovial sarcoma cell line in Western blotting analysis with DC50 < 10 nM and Dmax > 95%.
CW-3308 effectively inhibited cell growth in the G401 rhabdoid tumor cell line and the HS-SY-II synovial sarcoma cell line and is much more potent than BI-7273 in both cell lines.
CW-3308 50 mg/kg effectively depleted BRD9 in the tumor tissue by >90% at 3 h time point and by 45% at 24 h time point in the HS-SY-II synovial sarcoma xenograft tumor model.
Physicochemical Properties
|
M.Wt
|
800.91
|
|
Formula
|
C45H48N6O8
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
2-(2,6-Dioxopiperidin-3-yl)-6-((3-(4-(2-ethyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)-2,6-dimethoxybenzoyl)-3-azaspiro[5.5]undecan-9-yl)methyl)-6,7-dihydropyrrolo[3,4-f]isoindole-1,3(2H,5H)-dione
|
References
1. Changwei Wang, et al. J Med Chem. 2024 Aug 12. doi: 10.1021/acs.jmedchem.4c00971.
Contact Us
sales@probechem.com
