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Chemical Structure : CW15337
CAS No.: 1202764-38-2
Catalog No.: PC-20834Not For Human Use, Lab Use Only.
CW15337 is a potent and highly selective inhibitor of NF-κB-inducing kinase (NIK) with Ki of 25 nM in biochemical assays, does not inhibit IKKα or IKKβ kinase activity.
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|---|---|---|---|
| 5 mg | $288 | In stock | |
| 10 mg | $458 | In stock | |
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CW15337 is a potent and highly selective inhibitor of NF-κB-inducing kinase (NIK) with Ki of 25 nM in biochemical assays, does not inhibit IKKα or IKKβ kinase activity.
CW15337 downregulates Bcl-XL and increases sensitivity to venetoclax against esistant CLL cells.
The combination of CW15337 and ABT-199 (venetoclax) reversed the drug resistance observed when treating tumor cells with ABT-199 alone.
CLL cells derived from patients showed increased nuclear p52 and high sensitivity to CW15337.
| M.Wt | 294.36 | |
| Formula | C17H18N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(1-(2-aminopyrimidin-4-yl)indolin-6-yl)-2-methylbut-3-yn-2-ol |
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1. Marco Haselager, et al. Cell Death Differ. 2021 May;28(5):1658-1668.
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