Chemical Structure : CW85319
CAS No.:
CW85319
(CW 85319)
Catalog No.: PC-21581Not For Human Use, Lab Use Only.
CW85319 is a small-molecule compound that enhances Axin2's interaction with GSK3β, shows a high-affinity binding with Axin2 with Kd of 5.8 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CW85319 is a small-molecule compound that enhances Axin2's interaction with GSK3β, shows a high-affinity binding with Axin2 with Kd of 5.8 uM.
CW85319 effectively increased the binding interaction of Axin2 with GSK3β in a dose-dependent manner, increased the phosphorylation levels of Axin2 without altering its acetylation levels.
CW85319 triggers Axin2 ubiquitination and proteasomal degradation in colorectal cancer (CRC) cells.
CW85319 blocks Axin2-driven EMT programme and suppresses CRC cell motility behaviours.
CW85319 blocks Axin2-driven EM. CW85319 suppresses colorectal cancer cell proliferation by limiting Axin2-driven cell cycle progression.
Physicochemical Properties
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M.Wt
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411.52
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Formula
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C23H25NO4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-(5-(4-((2-(2-(2-hydroxyethoxy)ethoxy)ethyl)thio)phenyl)pyridin-3-yl)phenol
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References
1. Li-Zhi Cheng, et al. Br J Pharmacol. 2023 Dec;180(23):3071-3091.
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