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CX-5011

Chemical Structure : CX-5011

CAS No.: 1333382-30-1

CX-5011 (CX5011)

Catalog No.: PC-22790Not For Human Use, Lab Use Only.

CX-5011 is a potent, selective inhibitor of protein kinase CK2 with IC50 of <10 nM, induces cell death by apoptosis and acts synergistically with imatinib or the MEK-inhibitor U0126 in imatinib-resistant CML cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CX-5011 is a potent, selective inhibitor of protein kinase CK2 with IC50 of <10 nM, induces cell death by apoptosis and acts synergistically with imatinib or the MEK-inhibitor U0126 in imatinib-resistant CML cells.

Physicochemical Properties

M.Wt 362.32
Formula C20H11N4NaO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

sodium 5-(3-ethynylphenylamino)pyrimido[4,5-c]quinoline-8-carboxylate

References

1. Anderes K, et al. Biochemistry. 2011 Oct 4;50(39):8478-88.

2. Salizzato V, et al. Oncotarget. 2016 Apr 5;7(14):18204-18.

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