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Chemical Structure : CX4945
CAS No.: 1009820-21-6
Catalog No.: PC-45870Not For Human Use, Lab Use Only.
CX-4945 (Silmitasertib, CX4945) is a potent, selective, orally bioavailable, ATP-competitive inhibitor of protein kinase Casein Kinase 2 (CK2) with Ki of 0.38 nM, CK2α IC50 of 1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg (Free Sample) | $18 | In stock | |
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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CX4945 (Silmitasertib, CX-4945) is a potent, selective, orally bioavailable, ATP-competitive inhibitor of protein kinase Casein Kinase 2 (CK2) with Ki of 0.38 nM, CK2α IC50 of 1 nM.
CX4945 (Silmitasertib) displays good selectivity profile against a panel of 238 kinases.
CX4945 (Silmitasertib) attenuates PI3K/Akt signaling, blocks CK2-dependent HIF-1α transcription, caused cell cycle arrest and selectively induces apoptosis in cancer cells relative to normal cells.
CX4945 (Silmitasertib) exhibits antitumor efficacy in murine xenograft models.
| M.Wt | 349.7705 | |
| Formula | C19H12ClN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 35 mg/mL |
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| Chemical Name/SMILES |
Benzo[c]-2,6-naphthyridine-8-carboxylic acid, 5-[(3-chlorophenyl)amino]- |
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1. Pierre F, et al. J Med Chem. 2011 Jan 27;54(2):635-54.
2. Siddiqui-Jain A, et al. Cancer Res. 2010 Dec 15;70(24):10288-98.
3. Siddiqui-Jain A, et al. Mol Cancer Ther. 2012 Apr;11(4):994-1005.
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