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Chemical Structure : CYD-2-11
Catalog No.: PC-60924Not For Human Use, Lab Use Only.
CYD-2-11 is a novel potent, selective Bax agonist that targets the structural pocket proximal to S184 in the C-terminal region of Bax (Ki=34.1 nM).
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CYD-2-11 is a novel potent, selective Bax agonist that targets the structural pocket proximal to S184 in the C-terminal region of Bax (Ki=34.1 nM).
CYD-2-11 shows no affinity for other Bcl-2 family members.
CYD-2-11 directly activates Bax proapoptotic activity by inducing a conformational change enabling formation of Bax homooligomers in mitochondrial membranes.
CYD-2-11 suppresses malignant growth without evident significant toxicity to normal tissues in mutant KRAS-driven lung cancer models.
CYD-2-11 displays strong synergistic activity and overcomes rapalog resistance combined with RAD001.
| M.Wt | 358.397 | |
| Formula | C22H18N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Li R, et al. Cancer Res. 2017 Jun 1;77(11):3001-3012.
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