CZS-034 | PLK4 inhibitor | Probechem Biochemicals

Chemical Structure : CZS-034

CZS-034 (CZS034)

Catalog No.: PC-25889Not For Human Use, Lab Use Only.

CZS-034 is a highly potent. selective PLK4 inhibitor with IC50 of 0.2 nM, exhibits antiproliferative activities against MCF-7, BT474, and MDA-MB-231 cells with IC50 of 0.36, 1.35, and 2.88 uM respectively.

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Biological Activity

Physicochemical Properties

M.Wt	440.46
Formula	C21H22F2N8O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N6-(2,4-difluorobenzyl)-N4-(5-methyl-1H-pyrazol-3-yl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

References

1. Yin Sun, et al. Eur J Med Chem. 2022 Aug 5:238:114424.

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CZS-034 (CZS034)

Biological Activity

Physicochemical Properties

References

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