CZS-035 | PLK4 inhibitor | Probechem Biochemicals

Chemical Structure : CZS-035

CZS-035 (CZS035)

Catalog No.: PC-25888Not For Human Use, Lab Use Only.

CZS-035 is a potent, selective PLK4 inhibitor with binding IC50 of 0.7 nM for PLK4, shows strong antiproliferative activity on MCF-7 cells with IC50 of 0.65 uM.

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Biological Activity

CZS-035 is a potent, selective PLK4 inhibitor with binding IC50 of 0.7 nM for PLK4, shows strong antiproliferative activity on MCF-7 cells with IC50 of 0.65 uM.

Physicochemical Properties

M.Wt	439.47
Formula	C21H23F2N9
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N6-(2,4-difluorobenzyl)-N4-(5-methyl-1H-pyrazol-3-yl)-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

References

1. Sun Y, et, al. J Med Chem. 2023 Jun 22;66(12):8200-8221.

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CZS-035 (CZS035)

Biological Activity

Physicochemical Properties

References

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