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Chemical Structure : CZh226
Catalog No.: PC-35567Not For Human Use, Lab Use Only.
CZh226 (CZh-226) is a potent, selective inhibitor of p21-activated kinase 4 (PAK4) with Ki of 9 nM, displays 346-fold selectivity over PAK-1.
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CZh226 (CZh-226) is a potent, selective inhibitor of p21-activated kinase 4 (PAK4) with Ki of 9 nM, displays 346-fold selectivity over PAK-1.
CZh226 also exhibits excellent kinase spectrum selectivity against a panel of 54 kinases (<80% inhibition at 0.1 uM).
CZh226 potently inhibits the migration and invasion of A549 tumor cells by regulating the PAK4-directed downstream signaling pathways in vitro.
CZh226 (CZh-226) is a valuable research probe for the further biological investigation of group II PAKs.
| M.Wt | 411.894 | |
| Formula | C20H22ClN7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hao C, et al. J Med Chem. 2018 Jan 11;61(1):265-285.
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