Chemical Structure : CZh226 hydrochloride
CAS No.:
2231440-94-9
CZh226 hydrochloride
(CZh-226;CZh 226)
Catalog No.: PC-35566Not For Human Use, Lab Use Only.
CZh226 hydrochloride (CZh-226) is a potent, selective inhibitor of p21-activated kinase 4 (PAK4) with Ki of 9 nM, displays 346-fold selectivity over PAK-1.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CZh226 hydrochloride (CZh-226) is a potent, selective inhibitor of p21-activated kinase 4 (PAK4) with Ki of 9 nM, displays 346-fold selectivity over PAK-1.
CZh226 also exhibits excellent kinase spectrum selectivity against a panel of 54 kinases (<80% inhibition at 0.1 uM).
CZh226 potently inhibits the migration and invasion of A549 tumor cells by regulating the PAK4-directed downstream signaling pathways in vitro.
CZh226 (CZh-226) is a valuable research probe for the further biological investigation of group II PAKs.
Physicochemical Properties
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M.Wt
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448.352
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Formula
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C20H23Cl2N7O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-(6-Chloro-4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)- quinazolin-2-yl)(3-methylpiperazin-1-yl)methanone hydrochloride
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References
1. Hao C, et al. J Med Chem. 2018 Jan 11;61(1):265-285.
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