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CaMK1D-IN-18

Chemical Structure : CaMK1D-IN-18

CAS No.: 2692620-19-0

CaMK1D-IN-18

Catalog No.: PC-72908Not For Human Use, Lab Use Only.

CaMK1D-IN-18 is a potent, selective CaMK1D inhibitor with IC50 of 31 nM, >150-fold greater activity against CaMK1D than all non-CaMK1 kinases.

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    Biological Activity

    CaMK1D-IN-18 is a potent, selective CaMK1D inhibitor with IC50 of 31 nM, >150-fold greater activity against CaMK1D than all non-CaMK1 kinases.
    CaMK1D-IN-18 improves insulin sensitivity and glucose control in the diet-induced obesity mouse model after both acute and chronic administration.

    Physicochemical Properties

    M.Wt 483.017
    Formula C24H31ClN8O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (S)-2-(3-Aminopiperidin-1-yl)-4-((3,5-bis(2-cyanopropan-2-yl)phenyl)amino)pyrimidine-5-carboxamide Hydrochloride

    References

    1. Christophe Fromont, et al. J Med Chem. 2020 Jul 9;63(13):6784-6801.

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