Cabazitaxel (XRP6258) | Microtubule inhibitor

Chemical Structure : Cabazitaxel

CAS No.: 183133-96-2

Cabazitaxel (XRP6258, XRP 6258)

Catalog No.: PC-61247Not For Human Use, Lab Use Only.

Cabazitaxel (XRP6258) is a semi-synthetic taxane and microtubule inhibitor for the treatment of hormone-refractory prostate cancer.

Packing	Price	Stock
50 mg	$78	In stock
100 mg	$118	In stock
500 mg	$348	In stock
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Biological Activity

Cabazitaxel (XRP6258) is a semi-synthetic taxane and microtubule inhibitor for the treatment of hormone-refractory prostate cancer.
Cabazitaxel possesses a favorable pharmacokinetic and safety profile, and a decreased propensity for P-glycoprotein (Pgp)-mediated drug resistance.

Physicochemical Properties

M.Wt	835.93
Formula	C45H57NO14
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-((3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate

References

1. Villanueva C, et al. Drugs. 2011 Jul 9;71(10):1251-8.

2. Madan RA, et al. Clin Cancer Res. 2011 Jun 15;17(12):3892-902.

3. Bouchet BP, et al. Drugs Today (Barc). 2010 Oct;46(10):735-42.

Cabazitaxel (XRP6258, XRP 6258)

Biological Activity

Physicochemical Properties

References

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