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Cadazolid

Chemical Structure : Cadazolid

CAS No.: 1025097-10-2

Cadazolid (ACT-179811, ACT179811)

Catalog No.: PC-22350Not For Human Use, Lab Use Only.

Cadazolid (ACT-179811) is a first-in-class quinoxolidinone antibiotic and a potent inhibitor of C. difficile protein synthesis with IC50 of 0.38 uM in in vitro transcription/translation assay, MIC of <0.03 ug/mL against Clostridioides difficile ATCC 700057.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Cadazolid (ACT-179811) is a first-in-class quinoxolidinone antibiotic and a potent inhibitor of C. difficile protein synthesis with IC50 of 0.38 uM in in vitro transcription/translation assay, MIC of <0.03 ug/mL against Clostridioides difficile ATCC 700057.

Physicochemical Properties

M.Wt 585.56
Formula C29H29F2N3O8
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-1-cyclopropyl-6-fluoro-7-(4-((2-fluoro-4-(5-(hydroxymethyl)-2-oxooxazolidin-3-yl)phenoxy)methyl)-4-hydroxypiperidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

References

1. Rueedi G, et al. J Med Chem. 2024 May 16. doi: 10.1021/acs.jmedchem.4c00558.

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