Chemical Structure : Cagrilintide
CAS No.: 1415456-99-3
Catalog No.: PC-24754Not For Human Use, Lab Use Only.
Cagrilintide (AM833) is a long-acting amylin analogue as a nonselective amylin receptor (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist with binding IC50 of 170 and 223 pM, and cAMP EC50 of 348 and 287 pM for hAMY3R and hCTR respectively.
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Cagrilintide (AM833) is a long-acting amylin analogue as a nonselective amylin receptor (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist with binding IC50 of 170 and 223 pM, and cAMP EC50 of 348 and 287 pM for hAMY3R and hCTR respectively.
Cagrilintide has demonstrated interesting clinical performance on body weight and is intended to assist in treatment of obesity-probably in combination with semaglutide.
M.Wt | 4409.01 | |
Formula | C194H312N54O59S2 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
l-prolinamide, n-(19-carboxy-1-oxononadecyl)-l-.gamma.-glutamyl-l-lysyl-l-cysteinyl-l-asparaginyl-l-threonyl-l-alanyl-l-threonyl-l-cysteinyl-l-alanyl-l-threonyl-l-glutaminyl-l-arginyl-l-leucyl-l-alanyl-l-.alpha.-glutamyl-l-phenylalanyl-l-leucyl-l-arginyl-l-histidyl-l-seryl-l-seryl-l-asparaginyl-l-asparaginyl-l-phenylalanylglycyl-l-prolyl-l-isoleucyl-l-leucyl-l-prolyl-l-prolyl-l-threonyl-l-asparaginyl-l-valylglycyl-l-seryl-l-asparaginyl-l-threonyl-, cyclic (3->8)-disulfide |
1. Kruse T, et al. J Med Chem. 2021 Aug 12;64(15):11183-11194.
2. Fletcher MM,, et al. J Pharmacol Exp Ther. 2021 Jun;377(3):417-440.
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