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Cagrilintide acetate

Chemical Structure : Cagrilintide acetate

CAS No.:

Cagrilintide acetate (AM833 acetate)

Catalog No.: PC-24755Not For Human Use, Lab Use Only.

Cagrilintide acetate (AM833) is a long-acting amylin analogue as a nonselective amylin receptor (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist with binding IC50 of 170 and 223 pM, and cAMP EC50 of 348 and 287 pM for hAMY3R and hCTR respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Cagrilintide acetate (AM833) is a long-acting amylin analogue as a nonselective amylin receptor (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist with binding IC50 of 170 and 223 pM, and cAMP EC50 of 348 and 287 pM for hAMY3R and hCTR respectively.
Cagrilintide has demonstrated interesting clinical performance on body weight and is intended to assist in treatment of obesity-probably in combination with semaglutide.

Physicochemical Properties

M.Wt 4409.01 (free base)
Formula C194H312N54O59S2.xC2H4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

l-prolinamide, n-(19-carboxy-1-oxononadecyl)-l-.gamma.-glutamyl-l-lysyl-l-cysteinyl-l-asparaginyl-l-threonyl-l-alanyl-l-threonyl-l-cysteinyl-l-alanyl-l-threonyl-l-glutaminyl-l-arginyl-l-leucyl-l-alanyl-l-.alpha.-glutamyl-l-phenylalanyl-l-leucyl-l-arginyl-l-histidyl-l-seryl-l-seryl-l-asparaginyl-l-asparaginyl-l-phenylalanylglycyl-l-prolyl-l-isoleucyl-l-leucyl-l-prolyl-l-prolyl-l-threonyl-l-asparaginyl-l-valylglycyl-l-seryl-l-asparaginyl-l-threonyl-, cyclic (3->8)-disulfide

References

1. Kruse T, et al. J Med Chem. 2021 Aug 12;64(15):11183-11194.

2. Fletcher MM,, et al. J Pharmacol Exp Ther. 2021 Jun;377(3):417-440.

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