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Calicheamicin

Chemical Structure : Calicheamicin

CAS No.: 108212-75-5

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Calicheamicin (Calicheamicin γ1)

Catalog No.: PC-45655Not For Human Use, Lab Use Only.

Calicheamicin γ1 is an enediyne antitumor antibiotic that acts by binding to DNA and causes strand scission.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Calicheamicin γ1 is an enediyne antitumor antibiotic that acts by binding to DNA and causes strand scission; ADC payload used in development of antibody drug conjugates.

Physicochemical Properties

M.Wt 1368.348
Formula C55H74IN3O21S4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Carbamic acid, N-[(1R,4Z,8S,13E)-8-[[4,6-dideoxy-4-[[[2,6-dideoxy-4-S-[4-[(6-deoxy-3-O-methyl-α-L-mannopyranosyl)oxy]-3-iodo-5,6-dimethoxy-2-methylbenzoyl]-4-thio-β-D-ribo-hexopyranosyl]oxy]amino]-2-O-[2,4-dideoxy-4-(ethylamino)-3-O-methyl-α-L-threo-pento

References

1. Lambert JM, et al. Adv Ther. 2017 May;34(5):1015-1035.

2. Guffroy M, et al. Clin Cancer Res. 2017 Apr 1;23(7):1760-1770.

3. Damelin M, et al. Clin Cancer Res. 2015 Sep 15;21(18):4165-73.

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