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Calicheamicin

Chemical Structure : Calicheamicin

CAS No.: 108212-75-5

Calicheamicin (Calicheamicin γ1)

Catalog No.: PC-45655Not For Human Use, Lab Use Only.

Calicheamicin (Calicheamicin γ1) is an enediyne antitumor antibiotic that acts by binding to DNA and causes strand scission, an ADC payload used in development of antibody drug conjugates.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Calicheamicin (Calicheamicin γ1) is an enediyne antitumor antibiotic that acts by binding to DNA and causes strand scission, an ADC payload used in development of antibody drug conjugates.

Physicochemical Properties

M.Wt 1368.348
Formula C55H74IN3O21S4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Carbamic acid, N-[(1R,4Z,8S,13E)-8-[[4,6-dideoxy-4-[[[2,6-dideoxy-4-S-[4-[(6-deoxy-3-O-methyl-α-L-mannopyranosyl)oxy]-3-iodo-5,6-dimethoxy-2-methylbenzoyl]-4-thio-β-D-ribo-hexopyranosyl]oxy]amino]-2-O-[2,4-dideoxy-4-(ethylamino)-3-O-methyl-α-L-threo-pento

References

1. Lambert JM, et al. Adv Ther. 2017 May;34(5):1015-1035.

2. Guffroy M, et al. Clin Cancer Res. 2017 Apr 1;23(7):1760-1770.

3. Damelin M, et al. Clin Cancer Res. 2015 Sep 15;21(18):4165-73.

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