Chemical Structure : Calicheamicin
CAS No.:
108212-75-5
Calicheamicin
(Calicheamicin γ1)
Catalog No. : PC-45655Not For Human Use, Lab Use Only.
Calicheamicin γ1 is an enediyne antitumor antibiotic that acts by binding to DNA and causes strand scission.
Packing Price Stock Quantity 5 mg $680 In stock 0 1 2 3 4 5 10 mg $1200 In stock 0 1 2 3 4 5
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4565501
Biological Activity
Calicheamicin γ1 is an enediyne antitumor antibiotic that acts by binding to DNA and causes strand scission; ADC payload used in development of antibody drug conjugates.
Physicochemical Properties
M.Wt
1368.348
Formula
C55H74IN3O21S4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Carbamic acid, N-[(1R,4Z,8S,13E)-8-[[4,6-dideoxy-4-[[[2,6-dideoxy-4-S-[4-[(6-deoxy-3-O-methyl-α-L-mannopyranosyl)oxy]-3-iodo-5,6-dimethoxy-2-methylbenzoyl]-4-thio-β-D-ribo-hexopyranosyl]oxy]amino]-2-O-[2,4-dideoxy-4-(ethylamino)-3-O-methyl-α-L-threo-pento
References
1. Lambert JM, et al. Adv Ther. 2017 May;34(5):1015-1035.
2. Guffroy M, et al. Clin Cancer Res. 2017 Apr 1;23(7):1760-1770.
3. Damelin M, et al. Clin Cancer Res. 2015 Sep 15;21(18):4165-73.
Contact Us
sales@probechem.com
