Calpastatin stabilizer A36 | Calpastatin stabilizer

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Chemical Structure : Calpastatin stabilizer A36

Calpastatin stabilizer A36 (CAST stabilizer A36)

Catalog No.: PC-26465Not For Human Use, Lab Use Only.

Calpastatin stabilizer A36 is a brain-penetrant small molecule that selectively stabilizes the calpastatin-calpain-2 complex, restores mitochondrial function and mitigates neurodegeneration.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Calpastatin stabilizer A36 is a brain-penetrant small molecule that selectively stabilizes the calpastatin-calpain-2 complex, restores mitochondrial function and mitigates neurodegeneration.

Physicochemical Properties

M.Wt	471.34
Formula	C22H20Cl2N6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(2-((4-(2,4-dichlorophenyl)-5-morpholinopyrimidin-2-yl)amino)ethoxy)nicotinonitrile

References

1. Hu D, et al. Sci Adv. 2026 Mar 27;12(13):eaeb1174.

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Calpastatin stabilizer A36 (CAST stabilizer A36)

Biological Activity

Physicochemical Properties

References

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