Chemical Structure : Cap5-IN-1
CAS No.:
899930-30-4
Cap5-IN-1
Catalog No.: PC-27116Not For Human Use, Lab Use Only.
Cap5-IN-1 is a competitive, cellulo active inhibitor of bacterial cyclic oligonucleotide-based anti-phage signaling system (CBASS) effector nuclease Cap5, effectively blocks phage defenses in bacteria.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Cap5-IN-1 is a competitive, cellulo active inhibitor of bacterial cyclic oligonucleotide-based anti-phage signaling system (CBASS) effector nuclease Cap5, effectively blocks phage defenses in bacteria.
Cap5 is hypothesized to degrade genomic DNA in virally infected cells, leading to cell dearth through abortive infection.
Cap5-IN-1 inhibitscGAMP-activated nuclease activity of L. lactis Cap5 (LlCap5) with IC50 of 120 uM.
Cap5-IN-1 also inhibits PsCap5 from the plant pathogen Pseudomonas syringae with IC50 of 24 uM.
Cap5-IN-1 does not inhibit two unrelated restriction endonucleases XhoI and DpnI, as well as Cas9, an endonuclease that contains an HNH catalytic domain.
Cap5-IN-1 can enter the cytosol of Gram-negative bacteria and inhibits the activation of PsCap5.
Cap5-IN-1 promotes phage infection in CBASS-containing bacteria.
Physicochemical Properties
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M.Wt
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536.59
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Formula
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C31H28N4O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-((1-(2-((furan-2-ylmethyl)amino)-2-oxoethyl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)methyl)-N-(4-methylbenzyl)benzamide
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References
1. Zhang C, et al. iScience. 2026 Jun 1;29(6):116174.
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