Capromorelin (CP-424391) | Ghrelin receptor agonist

Chemical Structure : Capromorelin

CAS No.: 193273-66-4

Capromorelin (CP-424391, CP424391)

Catalog No.: PC-38623Not For Human Use, Lab Use Only.

Capromorelin (CP-424391) is a pyrazolinone-piperidine dipeptide growth hormone secretagogue and ghrelin receptor agonist with Ki value of 7 nM (hGHS-R1a), and EC50 vaule of 3 nM (rat pituicyte).

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10 mg	$88	In stock
25 mg	$148	In stock
50 mg	$238	In stock
100 mg	$398	In stock
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Biological Activity

Capromorelin (CP-424391) is a pyrazolinone-piperidine dipeptide growth hormone secretagogue and ghrelin receptor agonist with Ki value of 7 nM (hGHS-R1a), and EC50 vaule of 3 nM (rat pituicyte).
Capromorelin (CP-424391) increased plasma GH levels in an anesthesized rat model, with ED(50) values less than 0.05 mg/kg iv.
Capromorelin showed enhanced intestinal absorption in rodent models and exhibited superior pharmacokinetic properties, including high bioavailabilities

Physicochemical Properties

M.Wt	505.619
Formula	C28H35N5O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-amino-N-((R)-1-((R)-3a-benzyl-2-methyl-3-oxo-2,3,3a,4,6,7-hexahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)-3-(benzyloxy)-1-oxopropan-2-yl)-2-methylpropanamide

References

1. Carpino PA, et al. Bioorg Med Chem Lett. 2002 Nov 18;12(22):3279-82.

2. Pan LC, et al. Endocrine. 2001 Feb;14(1):121-32.

3. Carpino PA, et al. Bioorg Med Chem. 2003 Feb 20;11(4):581-90.

Capromorelin (CP-424391, CP424391)

Biological Activity

Physicochemical Properties

References

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