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Cardiogenol C hydrochloride

Chemical Structure : Cardiogenol C hydrochloride

CAS No.: 1049741-55-0

Cardiogenol C hydrochloride

Catalog No.: PC-42972Not For Human Use, Lab Use Only.

Cardiogenol C is a small cell-permeable molecule that selectively and efficiently induce mouse embryonic stem cells (ESCs) to differentiate into cardiomyocytes with EC50 of 0.1 uM, activates Wnt signaling pathway.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Cardiogenol C is a small cell-permeable molecule that selectively and efficiently induce mouse embryonic stem cells (ESCs) to differentiate into cardiomyocytes with EC50 of 0.1 uM, activates Wnt signaling pathway.
Cardiogenol C induces cardiac differentiation in P19 and in P19Cl6 cells, also induces hair bulge progenitor cells (HBPCs) to express transcription factors GATA4, Nkx2.5 and Tbx5.
Cardiogenol C Cardiogenol C might exert its effect by activating the Wnt signaling pathway through the suppression of Kremen1.

Physicochemical Properties

M.Wt 296.7527
Formula C13H17ClN4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 59 mg/mL

Chemical Name/SMILES

Ethanol, 2-[[2-[(4-methoxyphenyl)amino]-4-pyrimidinyl]amino]-, hydrochloride (1:1)

References

1. Jasmin, et al. Stem Cells Dev. 2010 Mar;19(3):403-12.

2. Yau WW, et al. Proteome Sci. 2011 Jan 19;9(1):3.

3. Mike AK, et al. Cell Physiol Biochem. 2014;33(1):205-21.

4. Wu X, et al. J Am Chem Soc. 2004 Feb 18;126(6):1590-1.

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