Chemical Structure : Carisbamate
CAS No.:
194085-75-1
Carisbamate
(RWJ-333369, RWJ333369)
Catalog No.: PC-28239Not For Human Use, Lab Use Only.
Carisbamate (RWJ-333369) is a neuromodulator possessing antiseizure and neuroprotective properties, blocks T-type voltage-gated calcium channels.
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Purity & Documentation Purity:
>98% (HPLC)
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Biological Activity
Carisbamate (RWJ-333369) is a neuromodulator possessing antiseizure and neuroprotective properties, blocks T-type voltage-gated calcium channels.
Carisbamate (RWJ-333369) inhibits kainic acid induced significant elevations in [Ca2+ ]i and long-lasting neuronal hyperexcitability in CA3 pyramidal neurons.
Carisbamate (RWJ-333369) suppresses spontaneous rhythmic epileptiform activity in hippocampal slices exposed to zero-Mg2+ or 4-aminopyridine.
Carisbamate (RWJ-333369) also protects murine hippocampal HT-22 cells against excitotoxic injury with glutamate.
Carisbamate (RWJ-333369) significantly decreases Ca2+ flux in human embryonic kidney tsA-201 cells transfected with Cav 3.1 (voltage-dependent T-type Ca2+ ) channels.
Carisbamate (RWJ-333369) inhibits glutamate transmission in the granule cell of the dentate gyrus.
Physicochemical Properties
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M.Wt
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215.63
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Formula
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C9H10ClNO3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-2-(2-Chlorophenyl)-2-hydroxyethyl carbamate
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References
1. Novak GP, et al. Neurotherapeutics. 2007 Jan;4(1):106-9.
2. Liu Y, et al. Epilepsy Res. 2009 Jan;83(1):66-72.
3. Deshpande LS, et al. Epilepsia. 2008 Oct;49(10):1795-802.
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