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Carotegrast

Chemical Structure : Carotegrast

CAS No.: 401904-75-4

Carotegrast (HCA2969, HCA-2969)

Catalog No.: PC-23193Not For Human Use, Lab Use Only.

Carotegrast (HCA2969) is a potent, selective, orally available alpha 4 integrin (α4 integrin) antagonist with KD/ IC50 of 0.32/5.8 nM, 0.46 nM/1.4 nM, and 0.2/26 nM for human integrin α4β1, human α4β7 and mouse α4β7 respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Carotegrast (HCA2969) is a potent, selective, orally available alpha 4 integrin (α4 integrin) antagonist with KD/ IC50 of 0.32/5.8 nM, 0.46 nM/1.4 nM, and 0.2/26 nM for human integrin α4β1, human α4β7 and mouse α4β7 respectively.

Physicochemical Properties

M.Wt 555.41
Formula C27H24Cl2N4O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-2-(2,6-Dichlorobenzamido)-3-(4-(6-(dimethylamino)-1-methyl-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)phenyl)propanoic acid

References

1. Halland N, et al. ACS Med Chem Lett. 2014 Jan 10;5(2):193-8.

2. Park SC, et al. World J Gastroenterol. 2018 May 7;24(17):1868-1880.

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