Chemical Structure : Carotegrast
CAS No.: 401904-75-4
Catalog No.: PC-23193Not For Human Use, Lab Use Only.
Carotegrast (HCA2969) is a potent, selective, orally available alpha 4 integrin (α4 integrin) antagonist with KD/ IC50 of 0.32/5.8 nM, 0.46 nM/1.4 nM, and 0.2/26 nM for human integrin α4β1, human α4β7 and mouse α4β7 respectively.
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Carotegrast (HCA2969) is a potent, selective, orally available alpha 4 integrin (α4 integrin) antagonist with KD/ IC50 of 0.32/5.8 nM, 0.46 nM/1.4 nM, and 0.2/26 nM for human integrin α4β1, human α4β7 and mouse α4β7 respectively.
| M.Wt | 555.41 | |
| Formula | C27H24Cl2N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-2-(2,6-Dichlorobenzamido)-3-(4-(6-(dimethylamino)-1-methyl-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)phenyl)propanoic acid |
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1. Halland N, et al. ACS Med Chem Lett. 2014 Jan 10;5(2):193-8.
2. Park SC, et al. World J Gastroenterol. 2018 May 7;24(17):1868-1880.

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