Cathepsin G inhibitor KPA

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Chemical Structure : Cathepsin G inhibitor KPA

Catalog No.: PC-22250Not For Human Use, Lab Use Only.

Cathepsin G inhibitor KPA is a potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G (CatG) with IC50 of 53 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Cathepsin G inhibitor KPA is a potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G (CatG) with IC50 of 53 nM.
Cathepsin G inhibitor KPA weakly inhibits chymotrypsin (Ki = 1.5 ± 0.2 μM), and poorly inhibits (<50% inhibition at 100 μM) thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase.

Physicochemical Properties

M.Wt	620.64
Formula	C36H33N2O6P
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	[2-[3-[[(1-benzoyl-4-piperidinyl)methylamino]carbonyl]-2-naphthalenyl]-1-(1-naphthalenyl)-2-oxoethyl]-phosphonic acid

References

1. Michael N Greco, et al. J Am Chem Soc. 2002 Apr 17;124(15):3810-1.

2. Son ED, et al. Dermatology. 2012;224(4):352-60.

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