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Cavosonstat

Chemical Structure : Cavosonstat

CAS No.: 1371587-51-7

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Cavosonstat (N91115, N-91115)

Catalog No.: PC-60035Not For Human Use, Lab Use Only.

Cavosonstat (N91115, N-91115) is a potent, orally bioavailable inhibitor of S-nitrosoglutathione reductase (GSNOR) and CFTR modulator.

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5 mg $98 In stock
10 mg $148 In stock
25 mg $258 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Cavosonstat (N91115, N-91115) is a potent, orally bioavailable inhibitor of S-nitrosoglutathione reductase (GSNOR) and CFTR modulator.
Cavosonstat promotes CFTR maturation and plasma membrane stability, with a mechanism of action complementary to CFTR correctors and potentiators.
Cavosonstat significantly increases cell surface expression of F508del-CFTR in vitro combined with CFTR correctors.

Physicochemical Properties

M.Wt 299.71
Formula C16H10ClNO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-Chloro-4-(6-hydroxy-2-quinolinyl)benzoic acid

References

1. Donaldson SH, et al. J Cyst Fibros. 2017 May;16(3):371-379.

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