Cbl-b-IN-1

Chemical Structure : Cbl-b-IN-1

CAS No.: 2368841-84-1

Catalog No.: PC-25785Not For Human Use, Lab Use Only.

Cbl-b-IN-1 is a potent, selective, small molecule inhibitor of E3 ligase Casitas B-lineage lymphoma proto oncogene B (CBL-B) with IC50 of <100 nM, shows binding selectivity over C-CBL.

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Biological Activity

Cbl-b-IN-1 is a potent, selective, small molecule inhibitor of E3 ligase Casitas B-lineage lymphoma proto oncogene B (CBL-B) with IC50 of <100 nM, shows binding selectivity over C-CBL.

Physicochemical Properties

M.Wt	498.63
Formula	C29H34N6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(5-Azaspiro[2.4]heptan-5-ylmethyl)-6-cyclopropyl-N-(3-(3-((4-methyl-4H-1,2,4-triazol-3-yl)methyl)oxetan-3-yl)phenyl)picolinamide

References

1. Patent WO2024105563 A1.

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Cbl-b-IN-1

Biological Activity

Physicochemical Properties

References

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