Cbl-b inhibitor 33

Chemical Structure : Cbl-b inhibitor 33

Catalog No.: PC-27095Not For Human Use, Lab Use Only.

Cbl-b inhibitor 33 is a potent, selective, inactive-state inhibitor of E3 ligase Casitas B-lineage lymphoma proto oncogene B (Cbl-b) with SPR Kd of 2.4 nM, has 14-fold selectivity over c-Cbl.

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Biological Activity

Cbl-b inhibitor 33 is a potent, selective, inactive-state inhibitor of E3 ligase Casitas B-lineage lymphoma proto oncogene B (Cbl-b) with SPR Kd of 2.4 nM, has 14-fold selectivity over c-Cbl.

Physicochemical Properties

M.Wt	539.60
Formula	C29H32F3N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-((1r,3r)-3-methoxy-1-(4-methyl-4H-1,2,4-triazol-3-yl)cyclobutyl)phenyl)-6-(((1-methylcyclobutyl)amino)methyl)-4-(trifluoromethyl)isoindolin-1-one

References

1. Liang J, et al. ACS Med Chem Lett. 2026 May 27;17(6):1258-1265.

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