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Chemical Structure : Ceefourin-1
CAS No.: 315702-40-0
Catalog No.: PC-20572Not For Human Use, Lab Use Only.
Ceefourin-1 is a highly selective inhibitor of multidrug resistance protein 4 (MRP4/ABCC4), inhibits the efflux of a broad range of MRP4 substrates.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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Ceefourin-1 is a highly selective inhibitor of multidrug resistance protein 4 (MRP4/ABCC4), inhibits the efflux of a broad range of MRP4 substrates.
Ceefourin-1 potentiates global cytosolic cAMP accumulation in BE(2)-C neuroblastoma cells following forskolin stimulation.
Ceefourin-1 is relatively non-toxic and well tolerated across a broad range of cell lines with IC50 values typically >50 μM.
Ceefourin-1 reverses 6-MP resistance conferred by MRP4 in HEK293-MRP4 cells, and Ceefourin-1 is more potent than MK-571.
Ceefourin-1 exhibits no activity against cell lines overexpressing P-gp (HEK293-Pgp), ABCG2 (HEK293-ABCG2), and MRP1 (MCF7-VP16).
| M.Wt | 294.41 | |
| Formula | C11H10N4S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-((benzo[d]thiazol-2-ylthio)methyl)-4-methyl-2,4-dihydro-3H-1,2,4-triazole-3-thione |
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1. Cheung L, et al. Biochem Pharmacol. 2014 Sep 1;91(1):97-108.
2. Jördens MS, et al. Glia. 2015 Nov;63(11):2092-2105.
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