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Cefiderocol

Chemical Structure : Cefiderocol

CAS No.: 1225208-94-5

Cefiderocol (CFDC, S-649266, S649266)

Catalog No.: PC-22835Not For Human Use, Lab Use Only.

Cefiderocol (CFDC, S-649266) is a siderophore cephalosporin antibiotic, has a potent activity against a broad range of aerobic Gram-negative bacterial species with MIC50 of <2 ug/mL.

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Biological Activity

Cefiderocol (CFDC, S-649266) is a siderophore cephalosporin antibiotic, has a potent activity against a broad range of aerobic Gram-negative bacterial species with MIC50 of <2 ug/mL.
Cefiderocol shows antibacterial activity against carbapenem-resistant strains of Enterobacteriaceae and nonfermenting bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii.
Cefiderocol has affinity mainly for penicillin-binding protein 3 (PBP3) of Enterobacteriaceae and nonfermenting bacteria similar to that of ceftazidime.

Physicochemical Properties

M.Wt 752.21
Formula C30H34ClN7O10S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(6R,7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-3-((1-(2-(2-chloro-3,4-dihydroxybenzamido)ethyl)pyrrolidin-1-ium-1-yl)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

References

1. Ito A, et al. Antimicrob Agents Chemother. 2017 Dec 21;62(1).

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