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Cerastecin B

Chemical Structure : Cerastecin B

CAS No.: 3014434-63-7

Cerastecin B

Catalog No.: PC-22208Not For Human Use, Lab Use Only.

Cerastecin B is a potent small molecule inhibitor of A. baumannii transporter MsbA with binding KD of 0.37 nM, is a potent and bactericidal against A. baumannii, including clinical carbapenem-resistant Acinetobacter baumannii isolates.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Cerastecin B is a potent small molecule inhibitor of A. baumannii transporter MsbA with binding KD of 0.37 nM, is a potent and bactericidal against A. baumannii, including clinical carbapenem-resistant Acinetobacter baumannii isolates.

Physicochemical Properties

M.Wt 778.89
Formula C38H42N4O10S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5,5'-(succinylbis(azanediyl))bis(2-((4-butylphenyl)sulfonamido)benzoic acid)

References

1. Hao Wang, et al. Nat Microbiol. 2024 Apr 22. doi: 10.1038/s41564-024-01667-0.

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