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Cerulenin

Chemical Structure : Cerulenin

CAS No.: 17397-89-6

Cerulenin

Catalog No.: PC-70282Not For Human Use, Lab Use Only.

Cerulenin is an antifungal antibiotic that inhibits fatty acid synthase (FASN), also blocks cellular proliferation of KRAS-associated lung cancer cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Cerulenin is an antifungal antibiotic that inhibits fatty acid synthase (FASN), also blocks cellular proliferation of KRAS-associated lung cancer cells.
Cerulenin induces pro-survival, Akt and ERK activation, in serum-deprived KRAS mutant cancer cells.
Cerulenin causes a dose-dependent decrease in HER2/neu protein levels in breast cancer cells.

Physicochemical Properties

M.Wt 223.27
Formula C12H17NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2R,3S)-3-((4E,7E)-nona-4,7-dienoyl)oxirane-2-carboxamide

References

1. Gouw AM, et al. Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4300-4305.

2. Yellen P, et al. Cancer Lett. 2014 Oct 28;353(2):258-63.

3. Menendez JA, et al. Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10715-20.

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