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Chemical Structure : Cevimeline hydrochloride
CAS No.: 107220-28-0
Catalog No.: PC-45939Not For Human Use, Lab Use Only.
Cevimeline hydrochloride is a potent M1-selective muscarinic agonist.
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Cevimeline hydrochloride is a potent M1-selective muscarinic agonist.
Cevimeline decreases the K+-evoked [3H]ACh release from hippocampal synaptosomes and increases the K+-evoked [3H]DA release from striatal synaptosomes.
Cevimeline attenuates cognitive dysfunctions in AF64A-treated rats with low toxicity.
| M.Wt | 235.774 | |
| Formula | C10H18ClNOS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Spiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane], 2'-methyl-, hydrochloride (1:1), (2'R,3R)-rel- |
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1. Ono S, et al. Eur J Pharmacol. 1988 Oct 11;155(1-2):77-84.
2. Fisher A, et al. Neurosci Lett. 1989 Jul 31;102(2-3):325-31.
3. Nakahara N, et al. Jpn J Pharmacol. 1989 Dec;51(4):539-47.
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