Cevipabulin | Tubulin inhibitor | Probechem Biochemicals

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Chemical Structure : Cevipabulin

CAS No.: 849550-05-6

Cevipabulin (TTI-237, TTI 237)

Catalog No.: PC-25976Not For Human Use, Lab Use Only.

Cevipabulin (TTI-237) is a microtubule-stabilizing agent by binding to the vinblastine site, also binds to a new site on α-tubulin, shows IC50 of 18-40 nM for cytotoxicity in a panel of human tumor cell lines.

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10 mg	$128	In stock
25 mg	$198	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Physicochemical Properties

M.Wt	464.83
Formula	C18H18ClF5N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-5-Chloro-6-(2,6-difluoro-4-(3-(methylamino)propoxy)phenyl)-N-(1,1,1-trifluoropropan-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

References

1. Nasrin SR, et al. Biochem Biophys Res Commun. 2019 Aug 27;516(3):760-764.

2. Kovalevich J, et al. J Pharmacol Exp Ther. 2016 May;357(2):432-50.

3. Yang J, et al. Sci Adv. 2021 May 19;7(21):eabg4168.

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Cevipabulin (TTI-237, TTI 237)

Biological Activity

Physicochemical Properties

References

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