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Chemocoxib A

Chemical Structure : Chemocoxib A

CAS No.: 960214-84-0

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Chemocoxib A

Catalog No.: PC-62881Not For Human Use, Lab Use Only.

Chemocoxib A is a highly potent, selective, cytotoxic COX-2 inhibitor with IC50 of 290 nM and 90 nM for wt mCOX-2 and R120Q COX-2 mutant respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Chemocoxib A is a highly potent, selective, cytotoxic COX-2 inhibitor with IC50 of 290 nM and 90 nM for wt mCOX-2 and R120Q COX-2 mutant respectively.
    Chemocoxib A shows no signigicant activity against COX-1, and COX-2 mutant V349L, V523I, and S530A.
    Chemocoxib A exhibits cytotoxicity in cancer cell culture, inhibits the growth of human tumor xenografts in nude mice.

    Physicochemical Properties

    M.Wt 924.397
    Formula C49H50ClN3O13
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Butanoic acid, 4-[[4-[[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl]amino]butyl]amino]-4-oxo-, (5R,5aR,8aR,9R)-5,5a,6,8,8a,9-hexahydro-8-oxo-9-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-5-yl ester

    References

    1. Uddin MJ, et al. ACS Chem Biol. 2016 Nov 18;11(11):3052-3060.

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