Chk1 PROTAC-2

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Chemical Structure : Chk1 PROTAC-2

Catalog No.: PC-21717Not For Human Use, Lab Use Only.

Chk1 PROTAC-2 is a potent Chk1 degrader with DC50 of 1.33 µM in A375 cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Chk1 PROTAC-2 is a potent Chk1 degrader with DC50 of 1.33 µM in A375 cells.
Chk1 degradation by PROTAC-2 is inhibited in the presence of MG132 and pomalidomide, suggesting that CHK1 degradation occurs via the proteasome and cereblon.

Physicochemical Properties

M.Wt	900.91
Formula	C43H44N14O9
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((4-(cyanomethyl)phenyl)amino)-6-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-N-((1-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)ethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methyl)pyrimidine-4-carboxamide

References

1. Sandipan Roy Chowdhury, et al. bioRxiv. 2024 Jan 1:2023.12.30.573733.

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Chk1 PROTAC-2

Biological Activity

Physicochemical Properties

References

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