Chlopynostat

Chemical Structure : Chlopynostat

CAS No.:

Catalog No.: PC-25162Not For Human Use, Lab Use Only.

Chlopynostat is a potent, selective HDAC1 inhibitor with IC50 of 67 nM, with no activity against HDAC6/8/10 (IC50>1000 nM).

Packing	Price	Stock
5 mg	$118	In stock
10 mg	$188	In stock
25 mg	$348	In stock
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Biological Activity

Chlopynostat is a potent, selective HDAC1 inhibitor with IC50 of 67 nM, with no activity against HDAC6/8/10 (IC50>1000 nM).
Chlopynostat promotes apoptosis of CLL cells by enhancing STAT4 and p66Shc expression.
Chlopynostat restores STAT4 and p66Shc expression in leukemic cells from CLL patients.
Chlopynostat promotes CLL cell apoptosis by preferentially inhibiting HDAC1.

Physicochemical Properties

M.Wt	404.85
Formula	C22H17ClN4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-Aminophenyl)-4-((7-chloro-4-oxoquinazolin-3(4H)-yl)methyl)benzamide

References

1. Rossi S, et al. Biomed Pharmacother. 2024 May;174:116537.

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Chlopynostat

Biological Activity

Physicochemical Properties

References

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