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Chemical Structure : Chromeceptin
CAS No.: 331859-86-0
Catalog No.: PC-61655Not For Human Use, Lab Use Only.
Chromeceptin (94G6) is a cell-permeable benzochromene that selectively impairs the viability and growth of IGF2 (insulin-like growth factor 2)-overexpressing hepatocellular carcinoma cells, binds to MFP-2, stimulates the expression of IGFBP-1 and SOCS-3 through activation of STAT6.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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Chromeceptin (94G6) is a cell-permeable benzochromene that selectively impairs the viability and growth of IGF2 (insulin-like growth factor 2)-overexpressing hepatocellular carcinoma cells, binds to MFP-2, stimulates the expression of IGFBP-1 and SOCS-3 through activation of STAT6.
Chromeceptin blocks insulin-induced adipogenesis in 3T3-L1 cells (100% blockage at <20 ng/uL) and selectively suppresses IGF2-dependent growth of HepG2 carcinoma cells (IC50=29 nM).
Chromeceptin is a potent IGF2 signaling inhibitor.
| M.Wt | 359.35 | |
| Formula | C19H16F3N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-amino-7-(dimethylamino)-4-[3-(trifluoromethyl)phenyl]-4H-chromene-3-carbonitrile |
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1. Choi Y, et al. Chem Biol. 2006 Mar;13(3):241-9.
2. Jung D, et al. Biochem J. 2012 Dec 15;448(3):409-16.
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