Ciapavir | Latency-reversing agent | Probechem Biochemicals

Chemical Structure : Ciapavir

Ciapavir (SBI-0953294, SBI 0953294)

Catalog No.: PC-72431Not For Human Use, Lab Use Only.

Ciapavir (SBI-0953294, cIAP1 antagonist for viral reactivation) is a bivalent, next-generation, Smac mimetic and antagonist of cIAP1 as latency-reversing agent (LRA), specifically and potently promote HIV-1 latency reversal activity both in vivo.

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Biological Activity

Ciapavir (SBI-0953294, cIAP1 antagonist for viral reactivation) is a bivalent, next-generation, Smac mimetic and antagonist of cIAP1 as latency-reversing agent (LRA), specifically and potently promote HIV-1 latency reversal activity both in vivo.
Ciapavir's latency reversal activity is dependent on the NIK-dependent NF-κB signaling.
Ciapavir exhibits substantially greater potency and efficacy as an LRA, inducing comparable levels of latency reversal at concentrations 10- to 1,000-fold lower than the first-generation molecule SBI-0637142, without an increase in cytotoxicity.
Ciapavir does not trigger cytokine release or T cell activation.
Ciapavir is capable of increasing latent HIV-1 expression in ART-treated BLT mice in vivo and may therefore prove useful in "shock and kill" approaches to HIV-1 cure.

Physicochemical Properties

M.Wt	1023.322
Formula	C54H70N8O8S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4S,4'S,7S,7'S,9aS,9a'S)-N,N'-((1S,1'S,2R,2'R)-(hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(8,8-dimethyl-4-((S)-2-(methylamino)propanamido)-5-oxooctahydropyrrolo[2,1-b][1,3]thiazepine-7-carboxamide)

References

1. Lars Pache, et al. Cell Rep Med. 2020 Jun 23;1(3):100037.

Ciapavir (SBI-0953294, SBI 0953294)

Biological Activity

Physicochemical Properties

References

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