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Chemical Structure : Ciapavir
Catalog No.: PC-72431Not For Human Use, Lab Use Only.
Ciapavir (SBI-0953294, cIAP1 antagonist for viral reactivation) is a bivalent, next-generation, Smac mimetic and antagonist of cIAP1 as latency-reversing agent (LRA), specifically and potently promote HIV-1 latency reversal activity both in vivo.
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Ciapavir (SBI-0953294, cIAP1 antagonist for viral reactivation) is a bivalent, next-generation, Smac mimetic and antagonist of cIAP1 as latency-reversing agent (LRA), specifically and potently promote HIV-1 latency reversal activity both in vivo.
Ciapavir's latency reversal activity is dependent on the NIK-dependent NF-κB signaling.
Ciapavir exhibits substantially greater potency and efficacy as an LRA, inducing comparable levels of latency reversal at concentrations 10- to 1,000-fold lower than the first-generation molecule SBI-0637142, without an increase in cytotoxicity.
Ciapavir does not trigger cytokine release or T cell activation.
Ciapavir is capable of increasing latent HIV-1 expression in ART-treated BLT mice in vivo and may therefore prove useful in "shock and kill" approaches to HIV-1 cure.
| M.Wt | 1023.322 | |
| Formula | C54H70N8O8S2 | |
| Appearance | Solid | |
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1. Lars Pache, et al. Cell Rep Med. 2020 Jun 23;1(3):100037.
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