Catalog No.: PC-73164Not For Human Use, Lab Use Only.
Cilengitide (EMD 121974) is a potent, selective, cyclic Arg-Gly-Asp peptide inhibitor of integrins αvβ3 and αvβ5 with IC50 4.1 and 70 nM, respectively.
Cilengitide (EMD 121974) is a potent, selective, cyclic Arg-Gly-Asp peptide inhibitor of integrins αvβ3 and αvβ5 with IC50 4.1 and 70 nM, respectively. Cilengitide increases endothelial monolayer permeability, exhibits antiangiogenic activity. Cilengitide synergizes with radioimmunotherapy to increase efficacy and apoptosis in breast cancer xenografts.
Physicochemical Properties
M.Wt
588.666
Formula
C27H40N8O7
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Month
Shipping
Solubility
Chemical Name/SMILES
References
1. Burke PA, et al. Cancer Res. 2002 Aug 1;62(15):4263-72.
2. Taga T, et al. Int J Cancer. 2002 Apr 10;98(5):690-7.
3. Lode HN, et al. Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1591-6.
4. Dechantsreiter MA, et al. J Med Chem. 1999 Aug 12;42(16):3033-40.
