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Chemical Structure : Cilengitide
CAS No.: 188968-51-6
Catalog No.: PC-73164Not For Human Use, Lab Use Only.
Cilengitide (EMD 121974) is a potent, selective, cyclic Arg-Gly-Asp peptide inhibitor of integrins αvβ3 and αvβ5 with IC50 4.1 and 70 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $348 | In stock | |
| 100 mg | $848 | In stock | |
| 1 g | Get quote |
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Cilengitide (EMD 121974) is a potent, selective, cyclic Arg-Gly-Asp peptide inhibitor of integrins αvβ3 and αvβ5 with IC50 4.1 and 70 nM, respectively.
Cilengitide increases endothelial monolayer permeability, exhibits antiangiogenic activity.
Cilengitide synergizes with radioimmunotherapy to increase efficacy and apoptosis in breast cancer xenografts.
| M.Wt | 588.666 | |
| Formula | C27H40N8O7 | |
| Appearance | Solid | |
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1. Burke PA, et al. Cancer Res. 2002 Aug 1;62(15):4263-72.
2. Taga T, et al. Int J Cancer. 2002 Apr 10;98(5):690-7.
3. Lode HN, et al. Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1591-6.
4. Dechantsreiter MA, et al. J Med Chem. 1999 Aug 12;42(16):3033-40.
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