Catalog No.: PC-42258Not For Human Use, Lab Use Only.
Ciliobrevin A (HPI-4) is a small molecule Hedgehog pathway inhibitor (IC50=7 uM) that acts downstream of Su(fu) to modulate Gli processing, activation or trafficking, inhibits AAA+ ATPase motor cytoplasmic dynein.
Ciliobrevin A (HPI-4) is a small molecule Hedgehog pathway inhibitor (IC50=7 uM) that acts downstream of Su(fu) to modulate Gli processing, activation or trafficking, inhibits AAA+ ATPase motor cytoplasmic dynein.
Ciliobrevin does not directly target Smo, blocks the proliferation of cerebellar granule neuron precursors expressing an oncogenic form of Smo.
Ciliobrevin disrupts spindle pole assembly and kinetochore-microtubule attachment, inhibits melanosome aggregation and peroxisome motility in cultured cells.
