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Ciliobrevin A

Chemical Structure : Ciliobrevin A

CAS No.: 302803-72-1

Ciliobrevin A (HPI-4;HH pathway inhibitor 4)

Catalog No.: PC-42258Not For Human Use, Lab Use Only.

A small molecule Hedgehog pathway inhibitor (IC50=7 uM) that acts downstream of Su(fu) to modulate Gli processing, activation or trafficking.

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Biological Activity

A small molecule Hedgehog pathway inhibitor (IC50=7 uM) that acts downstream of Su(fu) to modulate Gli processing, activation or trafficking; does not directly target Smo, blocks the proliferation of cerebellar granule neuron precursors expressing an oncogenic form of Smo; disrupts spindle pole assembly and kinetochore-microtubule attachment, inhibits melanosome aggregation and peroxisome motility in cultured cells; inhibits AAA+ ATPase motor cytoplasmic dynein.

Physicochemical Properties

M.Wt 358.1783
Formula C17H9Cl2N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 34 mg/mL

Chemical Name/SMILES

Benzenepropanenitrile, 2,4-dichloro-α-(3,4-dihydro-4-oxo-2(1H)-quinazolinylidene)-β-oxo-

References

1. Firestone AJ, et al. Nature. 2012 Mar 18;484(7392):125-9.

2. Hyman JM, et al. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14132-7.

4. Clippinger AJ, et al. Genes Dev. 2012 Sep 15;26(18):2015-26.

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