Chemical Structure : Ciliobrevin A
CAS No.: 302803-72-1
Catalog No.: PC-42258Not For Human Use, Lab Use Only.
A small molecule Hedgehog pathway inhibitor (IC50=7 uM) that acts downstream of Su(fu) to modulate Gli processing, activation or trafficking.
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10 mg | $64 | In stock | |
25 mg | $144 | In stock | |
50 mg | $256 | In stock | |
100 mg | $440 | In stock |
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A small molecule Hedgehog pathway inhibitor (IC50=7 uM) that acts downstream of Su(fu) to modulate Gli processing, activation or trafficking; does not directly target Smo, blocks the proliferation of cerebellar granule neuron precursors expressing an oncogenic form of Smo; disrupts spindle pole assembly and kinetochore-microtubule attachment, inhibits melanosome aggregation and peroxisome motility in cultured cells; inhibits AAA+ ATPase motor cytoplasmic dynein.
M.Wt | 358.1783 | |
Formula | C17H9Cl2N3O2 | |
Appearance | Solid | |
Storage |
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Solubility |
DMSO: ≥ 34 mg/mL |
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Chemical Name/SMILES |
Benzenepropanenitrile, 2,4-dichloro-α-(3,4-dihydro-4-oxo-2(1H)-quinazolinylidene)-β-oxo- |
1. Firestone AJ, et al. Nature. 2012 Mar 18;484(7392):125-9.
2. Hyman JM, et al. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14132-7.
4. Clippinger AJ, et al. Genes Dev. 2012 Sep 15;26(18):2015-26.
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