Ciliobrevin D | Dynein inhibitor | Probechem Biochemicals

Chemical Structure : Ciliobrevin D

CAS No.: 1370554-01-0

Ciliobrevin D (Dynein inhibitor)

Catalog No.: PC-62398Not For Human Use, Lab Use Only.

Ciliobrevin D is a cell-permeable, reversible, specific inhibitor of AAA+ ATPase cytoplasmic dynein, blocks dynein-dependent microtubule gliding and ATPase activity while sparing kinesin dependent cellular trafficking.

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Biological Activity

Ciliobrevin D is a cell-permeable, reversible, specific inhibitor of AAA+ ATPase cytoplasmic dynein, blocks dynein-dependent microtubule gliding and ATPase activity while sparing kinesin dependent cellular trafficking.
Ciliobrevin D selectively affects retrograde transport, inhibits the bidirectional transport of organelles along sensory axons and impairs NGF-mediated regulation of growth cones and axon branches.
Ciliobrevin D disrupts spindle pole focusing and kinetochore-microtubule attachment at 10-40 uM.

Physicochemical Properties

M.Wt	392.62
Formula	C17H8Cl3N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(7-chloro-4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)-3-(2,4-dichlorophenyl)-3-oxopropanenitrile

References

1. Sainath R, et al. Dev Neurobiol. 2015 Jul;75(7):757-77.

2. Melemedjian OK, et al. Mol Pain. 2014 Jul 4;10:45.

3. See SK, et al. ACS Chem Biol. 2016 Jan 15;11(1):53-60.

4. Firestone AJ, et al. Nature. 2012 Mar 18;484(7392):125-9.