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Chemical Structure : Ciliobrevin D
CAS No.: 1370554-01-0
Catalog No.: PC-62398Not For Human Use, Lab Use Only.
Ciliobrevin D is a cell-permeable, reversible, specific inhibitor of AAA+ ATPase cytoplasmic dynein, blocks dynein-dependent microtubule gliding and ATPase activity while sparing kinesin dependent cellular trafficking.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $358 | In stock | |
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| 100 mg | Get quote |
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Ciliobrevin D is a cell-permeable, reversible, specific inhibitor of AAA+ ATPase cytoplasmic dynein, blocks dynein-dependent microtubule gliding and ATPase activity while sparing kinesin dependent cellular trafficking.
Ciliobrevin D selectively affects retrograde transport, inhibits the bidirectional transport of organelles along sensory axons and impairs NGF-mediated regulation of growth cones and axon branches.
Ciliobrevin D disrupts spindle pole focusing and kinetochore-microtubule attachment at 10-40 uM.
| M.Wt | 392.62 | |
| Formula | C17H8Cl3N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-(7-chloro-4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)-3-(2,4-dichlorophenyl)-3-oxopropanenitrile |
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1. Sainath R, et al. Dev Neurobiol. 2015 Jul;75(7):757-77.
2. Melemedjian OK, et al. Mol Pain. 2014 Jul 4;10:45.
3. See SK, et al. ACS Chem Biol. 2016 Jan 15;11(1):53-60.
4. Firestone AJ, et al. Nature. 2012 Mar 18;484(7392):125-9.
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