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Chemical Structure : Cilobradine
CAS No.: 186097-54-1
Catalog No.: PC-45567Not For Human Use, Lab Use Only.
Cilobradine (DKAH-269) is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel, an open channel blocker of neuronal Ih and related cardiac If channels.
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|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $448 | In stock | |
| 100 mg | Get quote |
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Cilobradine (DKAH-269) is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel, an open channel blocker of neuronal Ih and related cardiac If channels.
Cilobradine (DKAH-269) strongly reduces the pacemaker diastolic depolarization rate and the cell's firing frequency.
| M.Wt | 519.0726 | |
| Formula | C28H39ClN2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
100 mM in H2O (51.9 mg/mL) |
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| Chemical Name/SMILES |
2H-3-Benzazepin-2-one, 3-[[(3S)-1-[2-(3,4-dimethoxyphenyl)ethyl]-3-piperidinyl]methyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-, hydrochloride (1:1) |
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1. Van Bogaert PP, et al. Eur J Pharmacol. 2003 Oct 8;478(2-3):161-71.
2. El-Kholy W,et al. Mol Endocrinol. 2007 Mar;21(3):753-64.
3. Cheng Y, et al. J Pharmacol Exp Ther. 2007 May;321(2):469-76.
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