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Cilobradine

Chemical Structure : Cilobradine

CAS No.: 186097-54-1

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Cilobradine (DK-AH 269;DKAH-269)

Catalog No.: PC-45567Not For Human Use, Lab Use Only.

Cilobradine (DKAH-269) is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel, an open channel blocker of neuronal Ih and related cardiac If channels.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Cilobradine (DKAH-269) is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel, an open channel blocker of neuronal Ih and related cardiac If channels.
Cilobradine (DKAH-269) strongly reduces the pacemaker diastolic depolarization rate and the cell's firing frequency.

Physicochemical Properties

M.Wt 519.0726
Formula C28H39ClN2O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

100 mM in H2O (51.9 mg/mL)
Chemical Name/SMILES

2H-3-Benzazepin-2-one, 3-[[(3S)-1-[2-(3,4-dimethoxyphenyl)ethyl]-3-piperidinyl]methyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-, hydrochloride (1:1)

References

1. Van Bogaert PP, et al. Eur J Pharmacol. 2003 Oct 8;478(2-3):161-71.

2. El-Kholy W,et al. Mol Endocrinol. 2007 Mar;21(3):753-64.

3. Cheng Y, et al. J Pharmacol Exp Ther. 2007 May;321(2):469-76.

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