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Cilomilast

Chemical Structure : Cilomilast

CAS No.: 153259-65-5

Cilomilast (SB-207499;SB207499;SB 207499)

Catalog No.: PC-42698Not For Human Use, Lab Use Only.

Cilomilast (SB207499) is a potent and selective PDE4 inhibitor with IC50 of 95/120 nM for LPDE4/HPDE4.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Cilomilast (SB207499) is a potent and selective PDE4 inhibitor with IC50 of 95/120 nM for LPDE4/HPDE4.
Cilomilast (SB207499) shows selectivity for PDE4 over the other PDE isozymes and is 75-fold more selective than (R)-rolipram with respect to LPDE4 activity versus HPDE4 activity.
Cilomilast (SB207499) inhibits antigen-induced bronchoconstriction in conscious guinea pigs at 30 mg/kg and orally acitive.

Physicochemical Properties

M.Wt 343.4168
Formula C20H25NO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Cyclohexanecarboxylic acid, 4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, cis-

References

1. Christensen SB, et al. J Med Chem. 1998 Mar 12;41(6):821-35.

2. Barnette MS, et al. J Pharmacol Exp Ther. 1998 Jan;284(1):420-6.

3. Griswold DE, et al. J Pharmacol Exp Ther. 1998 Nov;287(2):705-11.

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